CONTEXT

Alexandra Durr and Sandrine Humbert’s team focus on neurogenetic diseases, spinocerebellar degenerations (spastic paraplegias and cerebellar ataxias) and Huntington disease. These rare conditions share clinical, genetic and functional characteristics but are extremely heterogeneous both in molecular and clinical aspects. The genetic group is interested in understanding causes and genetic factors of this variability thanks to a large cohort of 2000 families. The functional group explores the link between the genetic variants and the cellular consequences.
                  

POSITION

Under the supervision of the manager, the post-Doc will be in charge of : 

-          Identifying genetic causes of spinocerebellar degeneration using bioinformatic and statistical analysis.
-          Analysing RNA sequencing studies from several species, including human postmortem samples
-          Searching for genetic modifiers to explain clinical variability

For those missions, the entire team is composed by researchers in the field of neurosciences and clinical experts as well as dedicated platforms at the Institute.

·       Degree either MD or PhD or both
·       Acquired professional experience in biology, genetics and bioinformatics

 
KNOWLEDGE

·      Strong background in human genetics and knowledge of functional genomics
·       Proficiency in bioinformatics tools and statistics for genetic analysis (DNA and RNA)
·       Coding abilities with mastery of scripting languages (Bash, Python, R) 
·       Familiarity with database management and data integration
·       Experience in using nextflow pipelines would be a plus

 
SKILLS

·       You have a working knowledge of bioinformatic tools
·       You are familiar with biological pathways and experiences in animal models


SOFT SKILLS

·       Highly motivated
·       Rigorous and committed 
·       You have a sense of relationship, service to users and teamwork
·       You are autonomous 
·       You are passionate about the scientific environment

 
Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and respectful working environment for all diversities. 

All our positions are open to individuals with disabilities.
 

A detailed CV including a list of publications, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of references are to be send in a single one PDF directly on our career site:  https://offres.institutducerveau-icm.org/fr/jobs/1948-03